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Furthermore, the lobular distribution is dependent on dose with higher doses tending to produce centrilobular plus mid-lobular (Figure 4) and even panlobular hepatocellular hypertrophy

To determine if the presence of low concentrations of tamoxifen causes a differential increase of ROS levels in CHO R C5 versus AuxB1, cells were exposed for 24 h to tamoxifen (1 M and 5 M) and intracellular ROS was quantified using 2',7'-dichlorodihydrofluorescein diacetate (H 2 DCFDA) dye [38]

Lyall K, et al

To detect the inhibitory and drug toxicity of the compounds, Huh-7 cells expressing Luc-HBc were exposed to alkaloid compounds for 2 days, and luciferase activity and cell viability were detected to evaluate the effects of the compounds